La Jolla Pharmaceutical Company has created a collection of key articles on B cell tolerance. Summaries of these articles, written by LJP scientists, are indexed below.

Summaries of Selected Articles from the Scientific Literature

By: Andrew Wiseman, Ph.D., Matt Linnik, Ph.D., Mike Iverson, Ph.D., Mary-Ann Campbell, Ph.D.

• B Cell Activation, Tolerance and Antigen-presenting Function
  By Philip D. Hodgkin and Antony Basten
• B Cell Tolerance By Christopher C. Goodnow
• Elimination of Self-Reactive B Lymphocytes Proceeds in Two Stages: Arrested Development and Cell Death
  By Suzanne B. Hartley, Michael P. Cooke, David A. Fulcher, Alan W. Harris, Suzanne Cory, Antony Basten, and Christopher C. Goodnow
  
• Different Nuclear Signals are Activated by the B Cell Receptor during Positive Versus Negative Signaling
  By James I. Healy, Ricardo E. Doimetsch, Luika A. Timmerman, Jason G. Cyster, Mathew L. Thomas, Gerald R. Crabtree, Richard S. Lewis, and Christopher C. Goodnow
• Whither the Anergic B-cell
  By David A. Fulcher and Antony Basten
• Cross-linking of Membrane Immunoglobulin D, in the Absence of T C Help, Kills Mature B cells in Vivo
  By Fred D. Finkelman, Joanne M. Holmes, Oksana I. Dukhanina, and Suzanne C. Morris
  
• Engagement of the Antigen-Receptor on Immature Murine B Lymphocytes Results in Death by Apoptosis
  By Amanda Norvell, Laura Mandik and John B. Monroe
  
• Self-reactive B Cells Are Not Eliminated or Inactivated by Autoantigen Expressed on Thyroid Epithelial Cells
  By Srinivas Akkaraju, Karen Canaan, and Christopher C. Goodnow
  
• Autoreactive B Cell Regulation: Peripheral Induction of Development Arrest by Lupus-Associated Autoantigens
  By Sandra Santulli-Marotto, Marc W. Retter, Renelle Gee, Mark J. Mamula, and Stephen J. Clark
  
• Receptor Editing in a Transgenic Mouse Model: Site, Efficacy, and Role of B Cell Tolerance and Antibody Diversification
  By Roberta Pelanda, Stephen Schwers, Eiichiro Sonoda, Raul M.Torres, David Nemazee and Klaus Rajewsky
  
• A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-Independent Role for B Cells in Murine Lupus
  By Owen T. Chan, Lynn Hannum, Ann M. Haverman, Michael P. Madaio, and Mark J. Shlomchik
  
• How Self-Tolerance and the Immunosuppressive Drug FK506 Prevent B-cell Mitogenesis
  By Richard Glynne, Srinivas Akkaraju, James I. Healy, Jane Rayner, Christopher C. Goodnow, and David H. Mack
  
• T Cell-Independent Rescue of B Lymphocytes from Peripheral Immune Tolerance
  By Valerie Kouskoff, Georges Lacaud, and David Nemazee
  
• Pathways for Self-Tolerance and the Treatment of Autoimmune Diseases
  By Christopher C. Goodnow