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Company Abstracts :: 2001 :: Selected
Company Abstract
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SYNTHESIS
OF MULTIVALENT CARBONATE ESTERS BY DIVERGENT GROWTH OF BRANCHED
CARBAMATES
DS Jones, ME Tedder, CA Gamino, JR Hammaker and HT Ton-Nu. La Jolla
Pharmaceutical Company, San Diego, CA.
Multivalent 4-nitrophenyl (PNP)-carbonate esters were prepared from
carbonate ester-containing core groups by a new divergent-growth
process. The process doubles the number of PNP-carbonate esters
with each round of growth, or branching, which occurs by reacting
an N,N-dihydroxylalkyl amine with a PNP-carbonate ester. The resulting
N,N-dihydroxyalkyl carbamate contains two hydroxy groups for each
original PNP-cabonate ester. The hydroxyl groups are converted in
situ to PNP-carbonate esters, and the process can be repeated to
provide successive generations of dendrimer-like branched structures
of increased valence.
Published in
Tetrahedron Letters
2001 42: 2069-2072
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