SYNTHESIS OF A CYCLIC-THIOETHER PEPTIDE WHICH BINDS ANTI-CARDIOLIPIN ANTIBODIES.

David S. Jones,* Christina A. Gamino, Martina E. Randow, Edward J. Victoria, Lin Yu and Stephen M. Coutts.

La Jolla Pharmaceutical Company, 6455 Nancy Ridge Drive, San Diego, CA 92121, USA

Thioether cyclized peptide analogue, 1, was synthesized using solid phase FMOC chemistry on HMPB-MBHA resin. a-Methylproline was introduced as an FMOC-alanyl-a-methylproline dipeptide, and the thioether was incorporated as FMOC-protected thioether tetrapeptide intermediate, 8. Compound 1 has been shown to bind anti-cardiolipin antibodies. © 1998 Elsevier Science Ltd. All rights reserved.

Published in Tetrahedron Letters 39 (1998) 6107-6110.